Samuel Walkup (9 Oct 1758 - 16 May 1851) was the son of James Alexander Walkup and his wife Margaret Pickens. He was born in Mecklenburg, NC and moved to Madison Co., KY about 1793. Samuel served in the North Carolina line during the Revolutionary War. He married first Elizabeth Guthrie (2 Sep 1761 - 19 Aug 1797). He married second Nancy Patterson (25 Jan 1774 - 24 Mar 1838) in ? Co., KY 4 Aug 1801. After Nancy's death he married Margaret Bratton in Madison Co., KY 30 Oct 1840. Samuel and Nancy had the following children:

1. *Polly Walkup married Rice Harvey 10 Oct 1809 in Madison Co., KY

2. Robert Walkup (20 Mar 1791 - 2 Sep 1861) married Polly Laughlin 4 Mar 1814 in Madison Co., KY. They later moved to Boone Co., MO and then to Wheelock, Robertson Co., TX where he died.

3. *Samuel Walkup (11 Feb 1791 - 29 Nov 1854) married Polly Patton 10 Jun 1813 in Madison Co., KY

4. *Thomas Walkup (28 Apr 1802 - 12 Jan 1842) married Polly Smith 1 Dec 1828 in Madison Co., KY.

5. *Betsy Walkup (20 Apr 1804 - 25 Jun 1846) married Zachariah Herndon and moved to Missouri. She later returned to Madison County where she died.

6. *John Walkup (ca.1805 - 22 Nov 1844) married Lucinda Herndon 14 Aug 1831 in Madison Co., KY and moved to Paris, MO.

7. Mary Walkup (14 Sep 1806 - 26 Jan 1862) married Johnson Freeman 31 Dec 1844 in Madison Co., KY.

8. *James P. Walkup (20 Apr 1814 - 15 May 1861) married Sally Smith 4 Jun 1835 in Madison Co., KY. He later moved to Boone Co., MO and died there.

*These names have been verified to be children of Samuel Walkup. Robert and Mary were found in published genealogies on the internet, but there was no documentation found to verify that relationship. Mary, however, was buried in the same cemetery as Samuel and Nancy.